Clinicopathologic Features of Never-Smoking Women Lung Cancer (WLC): A Review from the Spanish World07 Database

Re: environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women.

BACKGROUND Exposure to environmental tobacco smoke (ETS) is considered to be a major lung cancer risk factor for never smokers. We investigated the hypothesis that never-smoking women who are exposed to ETS and develop lung cancer are a genetically susceptible population. METHODS Archival tumor tissues were analyzed from 106 never-smoking women enrolled in a case-control study of ETS (and oth...

Evaluation of the risk of lung cancer due to hookah smoking: a meta-analysis study

Background: Hookah smoking has been growing among people because consumers believe that smoking in the form of hookahs has lesser health effects than cigarettes. However, recent reports showed that water pipe smoking (WSP) increased heart rate, blood pressure, impaired pulmonary function and carbon monoxide intoxication. Chronic bronchitis, emphysema and coronary artery disease are serious prob...

The Incidence of Lung Cancer and Smoking in Iran, Turkey, England, and USA: A Comparative Study

Introduction: lung cancer is the deadliest and the costliest cancer in the world. In this study, we have tried to compare the situation of this disease in several countries by considering the most important risk factor of lung cancer (smoking cigarette). Method: This is a comparative study, a comprehensive one which was done on lung cancer rates in four countries, Iran, Turkey, England and UAS...

Title Clinicopathologic Features of Non-Small-Cell Lung Cancer

Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients.

Aberrant methylation in gene promoter regions leads to transcriptional inactivation of cancer-related genes and plays an integral role in tumorigenesis. This alteration has been investigated in lung tumors primarily from smokers, whereas only a few studies involved never-smokers. Here, we applied methylation-specific polymerase chain reaction to compare the frequencies of the methylated promote...